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Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic

Chao-Yuan Hsu1,2, Shin-Huei Fu1,2, Ming-Wei Chien2

  • 1National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli 350, Taiwan.

International Journal of Molecular Sciences
|May 7, 2020
PubMed

Insights

Altered mucosal immune balance contributes to colonic diseases. Targeting transcription factor post-translational modifications offers promising therapeutic strategies for inflammatory bowel diseases and colorectal cancer.

Area of Science:

  • Immunology
  • Molecular Biology
  • Gastroenterology

Background:

  • Mucosal immune balance is crucial for colonic health.
  • Imbalances are linked to inflammatory bowel diseases and colorectal cancer.
  • Transcription factors play key roles in colonic disease development.

Purpose of the Study:

  • To review the role of post-translational modifications in transcription factors relevant to colonic diseases.
  • To explore therapeutic implications of targeting these modifications.

Main Methods:

  • Literature review focusing on post-translational modifications of transcription factors.
  • Analysis of immunological and molecular mechanisms in colonic disease.

Main Results:

  • Post-translational modifications (phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, O-GlcNAcylation) significantly regulate transcription factors.
  • These modifications impact the etiology and pathophysiology of colonic diseases.

Conclusions:

  • Understanding post-translational regulation of transcription factors is key for novel therapeutic strategies.
  • Targeting these modifications presents a promising avenue for treating colonic diseases.
Keywords:
O-GlcNAcylationSUMOylationacetylationmethylationphosphorylationtranscription factorubiquitination

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