Related Experiment Video
Updated: Dec 22, 2025

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
Glyceraldehyde-3-phosphate Dehydrogenase is a Multifaceted Therapeutic Target
Vladimir F Lazarev1, Irina V Guzhova1, Boris A Margulis1
1Institute of Cytology of the Russian Academy of Sciences, St. Petersburg 194064, Russia.
Abstract:
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in pathologic processes needs further elucidation. Depending on the cell context, GAPDH may bind a number of physiologically important proteins, control their function and correspondingly affect the cell's fate. These interprotein interactions and post-translational modifications of GAPDH mediate its cytotoxic or cytoprotective functions in the manner of a Janus-like molecule. In this review, we discuss the functional features of the enzyme in cellular physiology and its possible involvement in human pathologies. In the last part of the article, we describe drugs that can be employed to modulate this enzyme's function in some pathologic states.
More Related Videos
Related Concept Videos
Other Glycolytic Pathways
Glycolysis: Preparatory Phase
Energy-releasing Steps of Glycolysis
The first energy-releasing step—the 6th step of glycolysis...
Glycolysis
What is Glycolysis?
Cells make energy by breaking down macromolecules. Cellular respiration is the biochemical process that converts "food energy" (from the chemical bonds of macromolecules) into chemical energy in the form of adenosine triphosphate (ATP). The first step of this tightly regulated and intricate process is glycolysis. The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). Glycolysis serves two main intracellular functions: generating ATP and generating...
Energy-requiring Steps of Glycolysis

