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Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in

Yin-Tso Liu1,2, Disline Manli Tantoh3,4, Lee Wang4

  • 1School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Nutrients
|May 7, 2020
PubMed

Insights

Coffee consumption may lower coronary heart disease (CHD) risk, particularly for individuals with the TRIB1 GG genotype. This genetic interaction highlights personalized prevention strategies for cardiovascular health.

Area of Science:

  • Genetics and Cardiovascular Health
  • Nutritional Epidemiology

Background:

  • Coronary heart disease (CHD) is influenced by genetic and lifestyle factors.
  • The role of specific genetic variants and dietary habits, like coffee consumption, in CHD risk requires further investigation.

Purpose of the Study:

  • To investigate the interaction between coffee consumption and the TRIB1 rs17321515 variant in relation to CHD risk.
  • To determine if coffee intake modifies CHD risk based on TRIB1 genotype.

Main Methods:

  • Utilized linked data from the National Health Insurance Research Database (NHIRD) for CHD cases and controls and the Taiwan Biobank (TWB) for genotype data.
  • Employed multivariate logistic regression to assess associations and interaction terms, with stratification by TRIB1 rs17321515 genotype.

Main Results:

  • Coffee consumption showed a trend towards lower CHD risk (OR 0.84; 95% CI 0.72-0.99).
  • No significant independent association was found between the TRIB1 rs17321515 variant and CHD.
  • A significant interaction (p=0.0330) revealed that coffee consumption was associated with reduced CHD risk only in individuals with the TRIB1 GG genotype (OR 0.62; 95% CI 0.45-0.85).

Conclusions:

  • Coffee consumption is linked to decreased coronary heart disease risk in Taiwanese adults.
  • This protective effect is particularly pronounced among individuals carrying the TRIB1 GG genotype, suggesting a gene-diet interaction.

Keywords:
CHDTRIB1Taiwan Biobankcoffee drinkingrs17321515

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