Related Experiment Video
Updated: Dec 22, 2025
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
Enhanced Visualization of Retinal Microvasculature in Optical Coherence Tomography Angiography Imaging via Deep
Shin Kadomoto1, Akihito Uji1, Yuki Muraoka1
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Background:
To investigate the effects of deep learning denoising on quantitative vascular measurements and the quality of optical coherence tomography angiography (OCTA) images.
Methods:
U-Net-based deep learning denoising with an averaged OCTA data set as teacher data was used in this study. One hundred and thirteen patients with various retinal diseases were examined. An OCT HS-100 (Canon inc., Tokyo, Japan) performed a 3 × 3 mm2 superficial capillary plexus layer slab scan centered on the fovea 10 times. A single-shot image was defined as the original image and the 10-frame averaged image and denoised image generated from the original image using deep learning denoising for the analyses were obtained. The main parameters measured were the OCTA image acquisition time, contrast-to-noise ratio (CNR), peak signal-to-noise ratio (PSNR), vessel density (VD), vessel length density (VLD), vessel diameter index (VDI), and fractal dimension (FD) of the original, averaged, and denoised images.
Results:
One hundred and twelve eyes of 108 patients were studied. Deep learning denoising removed the background noise and smoothed the rough vessel surface. The image acquisition times for the original, averaged, and denoised images were 16.6 ± 2.4, 285 ± 38, and 22.1 ± 2.4 s, respectively (P < 0.0001). The CNR and PSNR of the denoised image were significantly higher than those of the original image (P < 0.0001). There were significant differences in the VLD, VDI, and FD (P < 0.0001) after deep learning denoising.
Conclusions:
The deep learning denoising method achieved high speed and high quality OCTA imaging. This method may be a viable alternative to the multiple image averaging technique.
