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Updated: Dec 22, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Parathyroid nodules in a patient with chronic renal failure: Hyperplasia or neoplasia?
Naomi Ross1, Chung-Shan Leung1, Kalman Kovacs1
1Department of Pathology St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Abstract:
Enlarged parathyroid glands found at autopsy in a 69-year-old-old man with chronic renal failure and hyperparathyroidism were examined and compared with his parathyroidectomy specimens from 5 years previously. Histology, immunohistochemistry, and DNA analysis did not discriminate conclusively between nodular hyperplasia and adenoma. Although transformation of parathyroid hyperplasia to adenoma remains an attractive hypothesis, conclusive distinction between dependent secondary hyperparathyroidism and autonomous tertiary hyperparathyroidism cannot be made at present on the basis of morphology.
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