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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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ACR Appropriateness Criteria® Placenta Accreta Spectrum Disorder.

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Placenta accreta spectrum disorder (PASD) requires accurate antenatal diagnosis for optimal delivery planning. Imaging, including ultrasound, is crucial for managing this high-risk pregnancy condition.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Radiology

Background:

  • Placenta accreta spectrum disorder (PASD) is the recommended terminology for abnormally adherent placentas.
  • PASD involves abnormal placental implantation, with placenta accreta characterized by direct myometrial adherence of chorionic villi.
  • Accurate antenatal diagnosis is critical for reducing maternal and fetal morbidity and mortality.

Framework:

  • The International Federation of Obstetrics and Gynecology (FIGO) recommends PASD terminology.
  • The American College of Radiology Appropriateness Criteria provide evidence-based guidelines for imaging and treatment.
  • Methodologies like RAND/UCLA and GRADE are used to evaluate procedures.

Implementation:

  • Suspected PASD necessitates prompt radiologic and clinical data collection.
  • Transabdominal ultrasound with Doppler and transvaginal ultrasound are key diagnostic imaging procedures.
  • Expert opinion may supplement evidence when data is limited.

Implications:

  • Timely and accurate diagnosis facilitates appropriate delivery strategies at specialized centers.
  • Improved imaging protocols can enhance management of PASD.
  • Adherence to evidence-based guidelines ensures optimal patient care for PASD.