Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

527
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
527
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

476
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
476
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

497
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
497
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

782
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
782

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ellagic acid and montelukast mitigate arsenic trioxide-induced hepatotoxicity via modulation of oxidative stress, inflammatory pathways, and mitochondrial apoptosis.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

The Role of Volunteers in Providing Palliative Care Services in Iran: A Qualitative Study.

Journal of social work in end-of-life & palliative care·2026
Same author

A systematic review on the impact of type 2 diabetes on Leydig and Sertoli cells: Molecular mechanisms and functional consequences.

Diabetes & metabolic syndrome·2026
Same author

Digital integrated systems in primary health care: advancing universal health coverage in low- and middle-income countries.

EBioMedicine·2026
Same author

Pain management and its challenges in Iranian cancer patients: a mixed-method study.

BMJ open·2025
Same author

Preventive and therapeutic effects of cepharanthine on acetaminophen-induced acute liver and kidney injury in male laboratory mice.

Gastroenterology and hepatology from bed to bench·2025

Related Experiment Video

Updated: Dec 22, 2025

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals
07:39

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals

Published on: June 25, 2018

7.6K

Trace element nanoparticles improved diabetes mellitus; a brief report.

Hadis Ashrafizadeh1, Seyed Reza Abtahi2, Ali Akbar Oroojan3

  • 1Department of Nursing, School of Nursing and Midwifery, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

Diabetes & Metabolic Syndrome
|May 7, 2020
PubMed
Summary

Trace elements like zinc, copper, selenium, and magnesium show promise in managing diabetes mellitus. Their nanoparticle forms are particularly effective in treating diabetes and its complications.

Keywords:
DiabetesNanoparticleTrace element

More Related Videos

Isolated Pancreatic Islet Treatment and Apoptosis Measurement
09:36

Isolated Pancreatic Islet Treatment and Apoptosis Measurement

Published on: May 2, 2025

771
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
16:59

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer

Published on: October 10, 2012

12.0K

Related Experiment Videos

Last Updated: Dec 22, 2025

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals
07:39

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals

Published on: June 25, 2018

7.6K
Isolated Pancreatic Islet Treatment and Apoptosis Measurement
09:36

Isolated Pancreatic Islet Treatment and Apoptosis Measurement

Published on: May 2, 2025

771
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
16:59

Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer

Published on: October 10, 2012

12.0K

Area of Science:

  • Biochemistry
  • Nanotechnology
  • Endocrinology

Background:

  • Diabetes mellitus is a chronic metabolic disorder with widespread organ complications.
  • Trace elements including copper, zinc, selenium, and magnesium are vital in diabetes management.
  • Understanding the role of these elements is crucial for therapeutic strategies.

Purpose of the Study:

  • To investigate the efficacy of trace element nanoparticles in managing diabetes mellitus.
  • To explore the mechanisms by which these nanoparticles impact diabetes and its complications.
  • To review the current literature on zinc, copper, selenium, and magnesium in diabetes treatment.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, ScienceDirect, Google Scholar, and Scopus.
  • Articles published between 2011 and 2018 focusing on "zinc," "copper," "selenium," "magnesium," and "diabetes" were reviewed.
  • 16 articles and 1 book were selected based on predefined eligibility criteria.

Main Results:

  • Zinc, copper, selenium, and magnesium exhibit significant antidiabetic effects.
  • These elements improve diabetes-induced complications by enhancing antioxidant enzyme levels.
  • Improved glucose utilization and insulin sensitivity were observed with trace element supplementation.

Conclusions:

  • Trace elements (zinc, copper, selenium, magnesium) demonstrate antidiabetic properties.
  • Nanoparticle formulations of these trace elements show enhanced potency for diabetes treatment.
  • Further research into trace element nanoparticles could lead to novel therapeutic approaches for diabetes.