Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

Area of Science:

• Biomedical Engineering
• Materials Science
• Drug Delivery Systems

Background:

• Growing demand for personalized medicine and medical devices.
• On-demand triggerable drug delivery systems are increasingly important.
• Three-dimensional (3D) printing enables personalized dosage form development.

Purpose of the Study:

• To design, fabricate, and characterize a novel magnetically triggerable drug delivery device.
• To achieve active and repeatable control of localized drug release using magnetic fields.
• To evaluate the device's performance with an anti-cancer drug and in vitro cell studies.

Main Methods:

• Fabrication of a device combining a magnetic polydimethylsiloxane (PDMS) sponge cylinder and a 3D printed reservoir.
• Characterization of the device's triggerable drug release capabilities using magnetic fields.
• In vitro drug release studies with 5-fluorouracil (FLU) and cell culture experiments.

Main Results:

• The device demonstrated switchable "on" and "off" states for drug release controlled by magnetic field application.
• Rapid drug release (50% in 20 min) was achieved with magnetic contact on the side.
• Minimal drug release (10% in 12 h) occurred when the magnetic bar was at the bottom.
• Increased magnetic field strength correlated with higher drug release and enhanced anti-cancer effects on Trex cells.

Conclusions:

• The developed device offers a safe, long-term, triggerable, and reusable method for localized disease treatment.
• Magnetic field manipulation provides precise control over drug release kinetics.
• This technology holds promise for advanced localized cancer therapy and personalized medicine.