Related Experiment Video
Updated: Dec 22, 2025

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
PAP therapy increases the risk of transmission of COVID-19
1Sleep Disorders Center, Neurological Institute, Cleveland Clinic.
Insights
Positive airway pressure (PAP) therapy may transmit COVID-19. This study provides recommendations for safe home use, sleep clinics, and emergency ventilation, minimizing transmission risks for patients and healthcare providers.
Area of Science:
- Respiratory Medicine
- Infectious Disease Control
- Sleep Medicine
Background:
- Positive airway pressure (PAP) therapy systems are open, posing a risk of COVID-19 transmission through contact, droplet, and airborne routes.
- This risk is comparable to other aerosol-generating procedures like tracheal intubation and cardiopulmonary resuscitation.
- Established guidelines are crucial for managing PAP therapy during the COVID-19 pandemic.
Purpose of the Study:
- To outline medically prudent recommendations for the use of PAP therapy in patients with or suspected of having COVID-19.
- To address the safe application of PAP devices in home settings, sleep clinics, and emergency ventilation scenarios.
- To mitigate the risk of SARS-CoV-2 transmission associated with PAP therapy.
Main Methods:
- Review and synthesis of existing literature and clinical guidelines related to PAP therapy and COVID-19.
- Development of evidence-based recommendations for different patient populations and clinical settings.
- Consideration of PAP devices as potential alternatives to mechanical ventilation in emergencies.
Main Results:
- Specific recommendations are provided for the home use of PAP therapy in asymptomatic, suspected, and confirmed COVID-19 cases.
- Guidelines are detailed for sleep clinics and laboratory activities to prevent viral transmission.
- The emergency application of PAP devices as a substitute for ventilation is discussed with safety considerations.
Conclusions:
- PAP therapy requires careful management to prevent COVID-19 transmission.
- Implementing recommended precautions is essential for patient and healthcare worker safety.
- These guidelines support the continued, safe use of PAP therapy during the pandemic.
Abstract:
Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and cardiopulmonary resuscitation. Medically prudent recommendations have been established for home use of PAP therapy in asymptomatic patients and patients with suspected or confirmed COVID-19. Recommendations for sleep clinics and sleep laboratory activities are also discussed as well as the emergency use of PAP devices as a substitute for ventilation.
Related Concept Videos
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Sexually Transmitted Infections

