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Fluid Accumulation in Critically Ill Children.

Rashid Alobaidi1, Rajit K Basu2, Allan DeCaen1

  • 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alberta and Stollery Children Children's Hospital, Edmonton, AB, Canada.

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Summary
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Fluid accumulation is common in critically ill children and linked to increased mortality and adverse outcomes. Developing strategies to manage fluid overload is crucial for improving patient survival and recovery.

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Area of Science:

  • Pediatric Critical Care Medicine
  • Fluid Management in Critically Ill Patients
  • Renal Outcomes in Pediatrics

Background:

  • Fluid accumulation, or fluid overload, is a frequent complication in pediatric intensive care units (PICUs).
  • Understanding the patterns and consequences of fluid overload is essential for optimizing patient care.
  • Previous research has indicated a potential link between fluid overload and poor outcomes in critically ill children.

Purpose of the Study:

  • To characterize the patterns of fluid accumulation in critically ill children.
  • To investigate the association between the degree, timing, duration, and rate of fluid accumulation and patient outcomes, including mortality and morbidity.
  • To inform the development of targeted interventions for fluid management.

Main Methods:

  • A retrospective cohort study was conducted.
  • Data were collected from all children admitted to PICUs in Alberta, Canada, between January 1, 2015, and December 31, 2015.
  • Statistical analyses were performed to evaluate the relationship between fluid overload metrics and patient outcomes.

Main Results:

  • Fluid overload increased significantly over time in PICU patients, with a median of 16.42% by day 10.
  • Over 32% of patients experienced peak fluid overload greater than 10%, and over 9% exceeded 20%.
  • Peak fluid overload and the rate of fluid accumulation were significantly associated with increased PICU mortality, Major Adverse Kidney Events within 30 days, and longer durations of mechanical ventilation and PICU stay.

Conclusions:

  • Fluid accumulation is a common and significant issue in critically ill children.
  • The degree and rate of fluid accumulation are associated with adverse patient outcomes, including mortality and morbidity.
  • There is a critical need for evidence-based interventional strategies to mitigate the harmful effects of fluid overload in the PICU setting.