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The roles of resveratrol on cardiac mitochondrial function in cardiac diseases

Apiwan Arinno1,2,3, Nattayaporn Apaijai1,2, Siriporn C Chattipakorn1,2

  • 1Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

European Journal of Nutrition
|May 7, 2020
PubMed

Insights

Resveratrol may protect against left ventricular dysfunction by enhancing antioxidant defenses and improving mitochondrial function. Further clinical studies are needed to confirm its benefits for cardiovascular diseases.

Area of Science:

  • Cardiology
  • Mitochondrial Biology
  • Pharmacology

Background:

  • Left ventricular (LV) dysfunction is linked to conditions like myocardial infarction, diabetes, and certain drug therapies.
  • Overproduction of reactive oxygen species (ROS) disrupts mitochondrial function, leading to cell death and LV dysfunction.
  • Maintaining a balance between ROS production and antioxidant capacity is crucial for cardiac health.

Purpose of the Study:

  • To review the effects of resveratrol on cardiac mitochondrial function in cardiac pathologies.
  • To explore the potential of resveratrol in preventing and treating cardiovascular diseases.
  • To encourage clinical investigations into resveratrol's role in improving LV function.

Main Methods:

  • Comprehensive summary and discussion of in vitro, ex vivo, and in vivo studies.
  • Analysis of resveratrol's impact on antioxidant gene expression.
  • Evaluation of resveratrol's role in oxidative stress and mitochondrial function.

Main Results:

  • Resveratrol upregulates key antioxidant genes (heme oxygenase-1, superoxide dismutase, catalase, glutathione).
  • Evidence suggests resveratrol can mitigate damage caused by excessive ROS.
  • Studies indicate potential benefits for cardiac mitochondrial function under pathological conditions.

Conclusions:

  • Resveratrol shows promise in protecting cardiac mitochondria and improving LV function.
  • Further clinical trials are essential to validate these findings and establish therapeutic efficacy.
  • Resveratrol may offer a novel therapeutic strategy for cardiovascular diseases involving LV dysfunction.
Keywords:
Cardiac ischemia–reperfusion injuryCardiotoxicityChemotherapyMitochondriaResveratrol

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