Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Dec 22, 2025

Immunostaining of Dissected Zebrafish Embryonic Heart

Immunostaining of Dissected Zebrafish Embryonic Heart

Published on: January 10, 2012

Functional alterations and transcriptomic changes during zebrafish cardiac aging.

Xuelian Shao¹, Yu Fu¹, Jinmin Ma¹

¹Department of Genetics and Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.

|May 7, 2020

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microbial DNA analysis of paired blood-bronchoalveolar lavage fluid in post-HSCT patients with pneumonia implying application conditions of blood as a surrogate in pathogen detection.

Respiratory research·2026

Same author

Flaw Sensitivity of Tough and Self-Healing Hydrogels with Hierarchical Structure.

Polymer science & technology (Washington, D.C.)·2026

Same author

Targeted regulation of adipose tissue macrophages from an immunometabolic perspective: a novel therapeutic approach for obesity-related metabolic disorders.

Frontiers in immunology·2026

Same author

Long-term outcomes of interventional therapy for transplant renal artery stenosis: a 5-year follow-up study.

Renal failure·2026

Same author

Uniaxial tensile strain-insensitive and zero-birefringence cellulose acetate films via atom-economic isocyanate modification.

Carbohydrate polymers·2026

Same author

Development and validation of an interpretable machine learning-based model for predicting carbapenem-resistant <i>Acinetobacter baumannii</i> infection in postoperative ICU patients: a retrospective cohort study.

Frontiers in cellular and infection microbiology·2026

Same journal

Emodin alleviates radiation-induced pulmonary fibrosis by targeting cellular senescence via the mtDNA-cGAS-STING axis.

Biogerontology·2026

Same journal

Natural modulators of enhancer of zeste homolog 2 (EZH2): potential epigenetic regulators of aging-associated pathways.

Biogerontology·2026

Same journal

MSC-derived extracellular vesicles accelerate wound healing in senescent fibroblast cultures.

Biogerontology·2026

Same journal

A multi-ingredient food supplement slows age-dependent decline of mobility and influences gene expression in C. elegans.

Biogerontology·2026

Same journal

Correction: Hormetic efficacy of rutin to promote longevity in Drosophila melanogaster.

Biogerontology·2026

Same journal

Identifying potential drug targets for physical and cognitive frailty: an integrative analysis of CHARLS cohort, mendelian randomization, and gene colocalization.

Biogerontology·2026

See all related articles

Zebrafish cardiac aging begins around 24 months, showing increased DNA damage and inflammation. This study details zebrafish cardiac aging, aiding future drug target screening.

Area of Science:

Cardiovascular research
Aging biology
Zebrafish models

Background:

Aging significantly elevates cardiovascular disease risk in humans.
Zebrafish are increasingly utilized as a model organism for aging research.
Understanding cardiac aging in zebrafish is crucial but limited.

Purpose of the Study:

To validate aging-related markers for zebrafish cardiac aging studies.
To characterize the progression and regulation of cardiac aging in zebrafish.
To establish a foundation for novel cardiac aging models and drug screening.

Main Methods:

Validation of a panel of aging-related markers and assessment of their spatial-temporal specificity.
Analysis of cardiac aging hallmarks including DNA damage, inflammation, and mitochondrial function.

Keywords:

Aging-related markers Cardiac aging Functional alterations Transcriptomic changes

More Related Videos

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Published on: January 12, 2015

Heart Dissection in Larval, Juvenile and Adult Zebrafish, Danio rerio

Heart Dissection in Larval, Juvenile and Adult Zebrafish, Danio rerio

Published on: September 30, 2011

Related Experiment Videos

Last Updated: Dec 22, 2025

Immunostaining of Dissected Zebrafish Embryonic Heart

Immunostaining of Dissected Zebrafish Embryonic Heart

Published on: January 10, 2012

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Published on: January 12, 2015

Heart Dissection in Larval, Juvenile and Adult Zebrafish, Danio rerio

Heart Dissection in Larval, Juvenile and Adult Zebrafish, Danio rerio

Published on: September 30, 2011

Comparison of zebrafish cardiac aging gene expression profiles with those of rat hearts.

Main Results:

Cardiac aging in zebrafish initiates around 24 months of age.
Aging progression involves increased DNA damage, inflammatory response, and reduced mitochondrial function.
Zebrafish cardiac aging exhibits similarities to aging patterns observed in rat hearts.

Conclusions:

This study provides a comprehensive insight into zebrafish cardiac aging.
Validated markers and characterized aging processes in zebrafish hearts.
The findings support the use of zebrafish for developing cardiac aging models for pharmaceutical research.