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Estimands and inference in cluster-randomized vaccine trials

Kayla W Kilpatrick1, Michael G Hudgens1, M Elizabeth Halloran2,3

  • 1Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA.

Pharmaceutical Statistics
|May 7, 2020
PubMed
Summary

This study defines estimands for vaccine effects in cluster-randomized trials. It shows the direct vaccine effect is generally not estimable without assumptions, unlike overall, indirect, and total effects.

Keywords:
causal inferenceestimandsherd immunityspillovervaccine trials

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