Related Experiment Videos
Centrally applied histamine increases gastric acid secretion in rats
1Department of Pharmacology and Toxicology, University of Oulu, Finland.
Naunyn-Schmiedeberg'S Archives of Pharmacology
|July 1, 1988
Summary
Histamine administered centrally stimulates gastric acid secretion in rats via a vagal-dependent pathway. This central mechanism is more potent than peripheral histamine administration for increasing stomach acid output.
Area of Science:
- Neuroscience
- Gastroenterology
- Pharmacology
Background:
- Histamine is known to influence gastric acid secretion.
- The precise pathways involved in histamine's central effects on gastric acid secretion are not fully elucidated.
Purpose of the Study:
- To investigate the role of central histamine administration in stimulating gastric acid secretion.
- To determine if the central effects of histamine on gastric acid secretion are vagal-dependent.
Main Methods:
- Administration of histamine into the lateral and third cerebral ventricles of anesthetized rats.
- Comparison of central versus subcutaneous histamine administration.
- Assessment of gastric acid secretion in vagotomized rats.
Main Results:
- Central histamine administration stimulated gastric acid secretion in a dose-dependent manner.
- Subcutaneous histamine injections produced less pronounced increases in acid output.
- The central effects of histamine on gastric acid secretion were abolished by vagotomy.
Conclusions:
- Histamine stimulates gastric acid secretion through a central mechanism.
- This central pathway for stimulating gastric acid secretion is dependent on the vagus nerve.