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Updated: Dec 22, 2025
Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
Published on: July 4, 2021
Unexpected Observations: Probiotic Administration Greatly Aggravates the Reproductive Toxicity of
Lizhu Tang1,2, Shiwen Song1, Chenyan Hu3
1State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Abstract:
The present study exposed adult zebrafish to 0, 10, and 100 μg/L perfluorobutanesulfonate (PFBS) with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants.
