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Nanoadhesive layer to prevent protein absorption in a poly(dimethylsiloxane) microfluidic device.

Jae Bem You1, Byungjin Lee2, Yunho Choi3

  • 1Department of Chemical & Materials Engineering, University of Alberta, Edmonton, Alberta, T6G 1H9, Canada.

Biotechniques
|May 7, 2020
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Summary

This study introduces a nanolayer coating to prevent molecule adsorption in poly(dimethylsiloxane) (PDMS) microfluidic devices. This method ensures accurate chemical concentrations for sensitive biological experiments, like yeast cell responses.

Keywords:
PDMS microfluidicsdevice bondingnanoadhesive layerprotein absorptionyeast mating

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Area of Science:

  • Biomaterials Science
  • Microfluidics Engineering
  • Cell Biology

Background:

  • Poly(dimethylsiloxane) (PDMS) is a common material for microfluidic devices.
  • PDMS absorbs molecules, altering chemical concentrations within microfluidic channels.
  • This absorption interferes with precise control of reagents and cell responses.

Purpose of the Study:

  • To develop a simple method to prevent molecular adsorption in PDMS microfluidic devices.
  • To maintain accurate chemical concentrations for microfluidic applications.
  • To enhance the reliability of experiments using PDMS-based microfluidics.

Main Methods:

  • A nanolayer coating was applied to PDMS microfluidic channels using vapor-phase deposition.
  • The effectiveness of the nanolayer in preventing molecular adsorption was tested using fluorescent molecules.
  • Yeast cells were cultured in treated and untreated PDMS devices to assess biological responses.

Main Results:

  • The nanolayer coating effectively prevented the absorption of fluorescent molecules into PDMS.
  • Yeast cells in nanolayer-treated devices showed accurate concentration-dependent responses to mating pheromones.
  • Untreated PDMS devices failed to elicit proper yeast cell responses due to molecule adsorption.

Conclusions:

  • Vapor-phase deposited nanolayer treatment is a simple and effective solution to prevent molecule adsorption in PDMS microfluidics.
  • This technique ensures precise control of molecule concentrations, crucial for sensitive biological assays.
  • The method significantly broadens the applicability of PDMS microfluidic devices in research and diagnostics.