Related Experiment Videos
Sodium thiosulfate prevents cisplatin-induced hypomagnesemia
N L Wong1, V Mavichak, A B Magil
1Department of Medicine, Health Sciences Centre Hospital, University of British Columbia, Vancouver, Canada.
Nephron
|January 1, 1988
Summary
Sodium thiosulfate protects against cisplatin-induced kidney damage and low magnesium levels. This study in rats shows concurrent administration prevents hypomagnesemia and nephrotoxicity, suggesting clinical significance.
Area of Science:
- Nephrology
- Pharmacology
- Toxicology
Background:
- Cisplatin is a widely used chemotherapy agent with known nephrotoxic and hypomagnesemic side effects.
- Management of cisplatin-induced toxicities remains a clinical challenge.
- Sodium thiosulfate has been investigated for its potential protective properties.
Purpose of the Study:
- To evaluate the protective effects of sodium thiosulfate against cisplatin-induced hypomagnesemia and nephrotoxicity in a rat model.
- To compare the efficacy of intraperitoneal versus intravenous administration of sodium thiosulfate.
Main Methods:
- Four groups of male Wistar rats were used.
- Group I received sodium thiosulfate (400 mg/kg) intraperitoneally.
- Groups II, III, and IV received cisplatin (2.5 mg/kg) with varying sodium thiosulfate administration (intraperitoneal or intravenous).
- Plasma creatinine, glomerular filtration rate, and plasma magnesium levels were monitored.
Main Results:
- Sodium thiosulfate administration prevented the rise in plasma creatinine.
- Glomerular filtration rates in groups receiving sodium thiosulfate were comparable to controls.
- Hypomagnesemia and increased fractional excretion of magnesium were observed in the cisplatin-only group, but not in groups co-treated with sodium thiosulfate.
- Both intraperitoneal and intravenous sodium thiosulfate demonstrated protective effects.
Conclusions:
- Concurrent administration of sodium thiosulfate, either intraperitoneally or intravenously, effectively prevents cisplatin-induced hypomagnesemia and nephrotoxicity in rats.
- These findings suggest a potential clinical application for sodium thiosulfate in mitigating cisplatin's adverse effects.
- Sodium thiosulfate represents a promising adjunctive therapy for patients undergoing cisplatin chemotherapy.