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Updated: Dec 22, 2025
12:19
Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
1.8K
Interplay between inflammation and cancer.
Igor Piotrowski1,2, Katarzyna Kulcenty1,2, Wiktoria Suchorska1,3
1Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Garbary 15 Street, 61-866 Poznań, Poland.
Summary
Inflammation is a key factor in cancer development, influencing tumor growth and spread. This review explores how inflammatory processes and wound healing responses promote carcinogenesis and tumor progression.
Area of Science:
- Oncology
- Immunology
- Cancer Biology
Background:
- Tumor-promoting inflammation is a recognized hallmark of cancer.
- Both chronic and acute inflammatory processes significantly influence cancer development, progression, metastasis, and recurrence.
- Tumor invasive procedures like surgery and biopsy can enhance tumor cell survival, proliferation, and migration by inducing wound healing responses.
Purpose of the Study:
- To review current knowledge on the role of inflammation in carcinogenesis.
- To explore how inflammatory processes promote cancer growth and progression.
Main Methods:
- This is a review article.
- Literature search and synthesis of existing research on inflammation and cancer.
Main Results:
- Inflammatory processes are intricately linked to neoplastic transformation, tumor progression, and metastasis.
- Wound healing responses, while essential for normal tissue repair, stimulate tumor cell survival, angiogenesis, and extravasation in the tumor microenvironment.
- Specific immune responses and immune cells can actively promote tumor progression.
Conclusions:
- Inflammation plays a critical role in initiating and advancing cancer.
- Understanding the interplay between inflammation, wound healing, and the immune system is crucial for developing effective cancer therapies.
Keywords:
ANGPTL4, angiopoietin-like 4CDH1, cadherin 1COX, cyclooxygenaseCancerEMT, epithelail to mesenchymal transitionEP, receptor - prostaglandin receptorGI, gastrointensinal cancerIL-6, interleukin 6InflammationMPO, myeloperoxidaseNADPH, nicotynamide adenine dinucleotide phosphate hydrogenNFκB, nuclear factor kappa-light-chain-enhancer of activated B cellsNK, natural killer cellsNO, nitric oxideNSAIDs, non-steroidal anti-inflammatory drugsPGE2, prostaglandin E2PTHrP, parathyroid hormone related proteinRNS, reactive nitrogen speciesROS, reactive oxigen speciesSTAT3, signal transducer and activator of transcription 3TGF-β, transforming growth factor βTGFBRII, transforming growth factor, beta receptor IITNF-α, tumour necrosis factor αTNFR1, Tumor necrosis factor receptor 1TNFR2, Tumor necrosis factor receptor 2Tumor reccurenceVEGF, vascular endothelail growth factorbFGF, fibroblast growth factoriNOS, inducible nitric oxide synthaseMore Related Videos
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