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Distinct Synchronous Network Activity During the Second Postnatal Week of Medial Entorhinal Cortex Development.

Julia Dawitz1, Tim Kroon1, J J Johannes Hjorth1

  • 1Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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|May 7, 2020
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Summary

Spontaneous synchronized network activity (SSNA) in the medial entorhinal cortex (MEC) peaks during the second postnatal week in mice. Its mechanisms partially overlap with the first week but show distinct features, suggesting evolving functions in brain development.

Keywords:
GABAdevelopmentearly network oscillationsgiant depolarizing potentialsmedial entorhinal cortexsynchronization

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Computational Neuroscience

Background:

  • The medial entorhinal cortex (MEC) is crucial for spatial navigation and memory.
  • Spatiotemporal tuning of MEC cells emerges around the third postnatal week in rodents.
  • Spontaneous synchronized network activity (SSNA) is vital for neuronal circuit development before week 3.

Purpose of the Study:

  • To investigate the characteristics and mechanisms of SSNA in the mouse MEC during the second postnatal week.
  • To compare SSNA during the second postnatal week with that of the first postnatal week.
  • To understand the developmental trajectory of MEC network activity preceding eye opening and spatial exploration.

Main Methods:

  • In vitro electrophysiology and calcium imaging techniques were employed.
  • Single-cell resolution and multi-layer integration were utilized.
  • Pharmacological manipulations assessed the roles of glutamatergic and GABAergic signaling.

Main Results:

  • SSNA in the mouse MEC peaks during the second postnatal week and depends on ionotropic glutamatergic signaling.
  • Unlike the first postnatal week, MEC network activity during the second week drives neocortical (NeoC) rather than hippocampal networks.
  • GABAergic influence on SSNA is age- and receptor-dependent, rather than driving network activity.

Conclusions:

  • SSNA in the MEC exhibits partial mechanistic overlap but also unique features between the first and second postnatal weeks.
  • Emerging distinct mechanisms suggest evolving roles for the MEC in hippocampal-entorhinal circuitry maturation.
  • These findings provide insights into the developmental basis of spatial representation in the brain.