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Updated: Dec 22, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
New aspects of p38 mitogen activated protein kinase (MAPK) biology in lung inflammation
Robert Newton1, Neil S Holden1
1Department of Cell Biology & Anatomy, Institute of Infection, Immunity and Inflammation, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Abstract:
Lung inflammation features in asthma, chronic obstructive airways disease (COPD), acute respiratory distress syndrome (ARDS), cystic fibrosis (CF) and others. Whilst in asthma anti-inflammatory glucocorticosteroids are generally effective, certain individuals are steroid resistant and in COPD, ARDS and CF, as well as disease exacerbations caused by infection, there seems little benefit. We summarise recent advances in p38 mitogen activated protein kinase (MAPK) biology and document beneficial and possibly detrimental effects in respect of lung inflammation.
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