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Published on: December 13, 2019
Asymptomatic Left Ventricle Systolic Dysfunction
Jaskanwal D Sara1, Takumi Toya1,2, Riad Taher1
1Department of Cardiovascular Medicine, Mayo Clinic College of Medicine and Science Rochester, MN, US.
Insights
Early detection of asymptomatic left ventricular systolic dysfunction (ALVSD) is crucial for better heart failure outcomes. Managing stage B heart failure before symptoms appear can improve patient prognosis and reduce healthcare costs.
Area of Science:
- Cardiology
- Heart Failure Research
- Clinical Medicine
Background:
- Heart failure is a major cause of morbidity and mortality, with significant societal costs.
- Current guidelines focus on symptomatic heart failure, yet early intervention is needed.
- Asymptomatic left ventricular systolic dysfunction (ALVSD) represents an opportunity for early management.
Purpose of the Study:
- To clarify the definition and natural history of ALVSD (Stage B heart failure).
- To outline clinical tools for identifying patients with ALVSD.
- To highlight future research directions for ALVSD.
Main Methods:
- Review of current literature and guidelines on heart failure management.
- Analysis of diagnostic criteria for ALVSD.
- Discussion of therapeutic strategies for early intervention.
Main Results:
- ALVSD is characterized by depressed left ventricular systolic function without clinical symptoms.
- Early treatment initiation in ALVSD is associated with improved patient outcomes.
- Several clinical tools can aid in the identification of ALVSD.
Conclusions:
- Managing ALVSD is essential for improving long-term heart failure outcomes.
- Further research is needed to fully understand and manage this condition.
- Early identification and intervention in ALVSD can mitigate disease progression.
Abstract:
Heart failure is a common debilitating illness, associated with significant morbidity and mortality, rehospitalisation and societal costs. Current guidelines and position statements emphasise the management of patients with overt symptomatic disease, but the increasing prevalence of congestive heart failure underscores the need to identify and manage patients with early left ventricular dysfunction prior to symptom onset. Asymptomatic left ventricular systolic dysfunction (ALVSD), classified as stage B heart failure, is defined as depressed left ventricular systolic function in the absence of clinical heart failure. Early initiation of therapies in patients with presumed ALVSD has been shown to lead to better outcomes. In this article, the authors clarify issues surrounding the definition and natural history of ALVSD, outline clinical tools that may be of value in identifying patients with ALVSD and highlight potential opportunities for future investigations to better address aspects of our understanding of this complex syndrome.
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