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Ticagrelor: A safe option as part of triple therapy?

Mohammad Umar Farooq1

  • 1ChristianaCare Health System, Academic Affiliate of Sidney Kimmel Medical College, Thomas Jefferson University, Newark, DE, USA.

Clinics and Practice
|May 7, 2020
PubMed

Insights

Triple therapy (TT) combines anticoagulation with dual antiplatelet therapy for atrial fibrillation and coronary artery disease. This case reviews ticagrelor safety within TT, considering its bleeding risk.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Atrial fibrillation and coronary artery disease often require combined treatments.
  • Triple therapy (TT) involves anticoagulation plus dual antiplatelet therapy.
  • Ticagrelor, a P2Y12 inhibitor, offers ischemic event prevention but carries bleeding risks.

Purpose of the Study:

  • To describe a case of a 70-year-old male on TT with ticagrelor.
  • To review the literature on ticagrelor safety in TT.

Main Methods:

  • Case report.
  • Literature review.

Main Results:

  • Ticagrelor is effective in preventing ischemic events.
  • TT with ticagrelor may increase intracranial bleeding risk.
  • Further research is needed to fully elucidate safety profiles.

Conclusions:

  • Ticagrelor is a viable option in TT for select patients.
  • Careful patient selection and monitoring are crucial.
  • Balancing ischemic and bleeding risks is paramount in TT management.

Keywords:
Cardiovascular disease (cardiology)antiplatelet therapyclinical decision makingclinical pharmacologytriple therapy

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