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Outbreak of COVID-19 infection in children: fear and serenity

P Pavone1, M Ceccarelli, R Taibi

  • 1Section of Pediatrics and Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. gnunnari@unime.it.

European Review for Medical and Pharmacological Sciences
|May 7, 2020
PubMed

Insights

Children infected with SARS-CoV-2, the virus causing COVID-19, generally experience milder illness. Current antiviral treatments show limited effectiveness in pediatric cases, necessitating further research.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • The SARS-CoV-2 pandemic has strained global healthcare systems, affecting all age groups.
  • COVID-19 presents in three stages: mild, moderate respiratory, and severe pneumonia.
  • Children typically exhibit less severe SARS-CoV-2 infections compared to adults.

Purpose of the Study:

  • To review and highlight the distinct clinical manifestations of COVID-19 in children versus adults.
  • To underscore the challenges in treating pediatric SARS-CoV-2 infections.

Main Methods:

  • Literature review focusing on pediatric COVID-19 cases.
  • Comparative analysis of clinical presentations and treatment outcomes in children and adults.

Main Results:

  • SARS-CoV-2 infection demonstrates lower susceptibility and reduced severity in pediatric populations.
  • Existing antiviral therapies, including interferon, lopinavir/ritonavir, orbidol, and oseltamivir, have shown insufficient efficacy in treating children with coronavirus infections.
  • No specific effective antiviral drug treatments are currently available for affected children.

Conclusions:

  • COVID-19 presents differently in children compared to adults, often with a more benign course.
  • The lack of effective antiviral treatments for pediatric SARS-CoV-2 infections is a significant clinical concern.
  • Further research is crucial to develop targeted and effective therapeutic strategies for children affected by SARS-CoV-2.
Abstract

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