Related Experiment Videos
Ultrahigh packing density next generation microtube array membrane: A novel solution for absorption-based
Chee Ho Chew1,2, Li-Wei Cheng1, Wan-Ting Huang1,2
1Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Summary
A novel polysulfone microtube array membrane alternating (MTAM-A) with immobilized polymyxin B (PMB) shows high endotoxin removal efficiency for sepsis treatment. This affordable hemoperfusion device offers a promising alternative to costly existing treatments.
Area of Science:
- Biomedical Engineering
- Materials Science
- Infectious Diseases
Background:
- Sepsis, a life-threatening condition, is often caused by endotoxins from gram-negative bacteria.
- Current treatments include antibiotics and vasopressors, with emerging membrane-based endotoxin removal devices.
- Existing membrane devices are expensive, limiting accessibility.
Purpose of the Study:
- To develop and evaluate an affordable and efficient endotoxin removal device for sepsis treatment.
- To assess the performance of a novel polysulfone microtube array membrane alternating (MTAM-A) with immobilized polymyxin B (PMB).
Main Methods:
- Fabrication of polysulfone (PSF) microtube array membrane alternating (MTAM-A) with immobilized polymyxin B (PMB).
- Assembly of the PSF MTAM-A into a hemoperfusion device.
- Testing endotoxin removal efficiency in water and blood models, benchmarking against the Toraymyxin device.
Main Results:
- Successful fabrication of PSF MTAM-A with 2.3 times the surface area of conventional membranes.
- Demonstrated overall endotoxin removal capacity of 90%.
- Achieved significantly higher endotoxin removal efficiency compared to the Toraymyxin device.
Conclusions:
- The developed PSF MTAM-A PMB hemoperfusion device is efficient, compact, and potentially affordable.
- This technology could significantly improve accessibility to life-saving sepsis treatments.
- Further application in hemoperfusion devices holds promise for widespread public benefit.