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Updated: Dec 22, 2025
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study
Eirini Marouli1,2, Aleksander Kus3,4,5, Fabiola Del Greco M6
1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Summary
Genetically predicted normal thyroid function influences stroke risk, mediated by atrial fibrillation. Hashimoto's thyroiditis increases coronary artery disease risk, primarily through body mass index.
Area of Science:
- Cardiovascular epidemiology
- Endocrinology
- Genetic epidemiology
Background:
- Observational studies link normal range thyroid function variations to cardiovascular diseases.
- Causality and mediating pathways remain undetermined.
Purpose of the Study:
- To investigate causal associations between genetically determined normal range thyroid function and stroke/coronary artery disease (CAD) risk.
- To explore mediating pathways for these relationships.
Main Methods:
- Mendelian randomization analyses utilized genetic instruments for thyrotropin (TSH), free thyroxine (FT4), Hashimoto's thyroiditis, and Graves' disease.
- Examined mediation by known stroke and CAD risk factors using publicly available summary statistics.
Main Results:
- A 1-SD increase in TSH was associated with a 5% reduced stroke risk, primarily mediated by atrial fibrillation.
- No causal link was found between normal range thyroid function and CAD.
- Hashimoto's thyroiditis showed a causal relationship with a 7% increased CAD risk, mediated by body mass index.
Conclusions:
- Normal range thyroid function variations are identified as risk factors for stroke.
- Hashimoto's thyroiditis is a risk factor for CAD.
- Elucidates causal relationships and mediating pathways between thyroid function and cardiovascular diseases.
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