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Updated: Dec 22, 2025

Hydrophobic Salt-modified Nafion for Enzyme Immobilization and Stabilization

Hydrophobic Salt-modified Nafion for Enzyme Immobilization and Stabilization

Published on: July 11, 2012

Stabilizing DNAzymes through Encapsulation in a Metal-Organic Framework.

Huiye Zhong¹, Wei-Shang Lo², Tiantian Man¹

¹Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P.R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|May 7, 2020

Summary

This summary is machine-generated.

Stabilizing DNAzymes within metal-organic frameworks (MOFs) enhances their structural integrity and catalytic activity. This biomimetic approach enables DNAzyme applications under diverse conditions, including continuous-flow systems.

Keywords:

DNAzymes continuous-flow conditions metal-organic frameworks reactivation stabilization

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Last Updated: Dec 22, 2025

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Published on: September 5, 2014

Area of Science:

Biomimetic catalysis
Nanomaterials for catalysis
Catalyst stabilization

Background:

DNAzymes are bioinspired catalysts with potential applications in various industries.
Structural instability of DNAzymes limits their practical utility under harsh conditions.
Developing methods to enhance DNAzyme stability is crucial for broader applications.

Purpose of the Study:

To develop a method for stabilizing DNAzymes using metal-organic frameworks (MOFs).
To demonstrate the enhanced stability and activity of encapsulated DNAzymes.
To explore the potential of stabilized DNAzymes in continuous-flow catalysis and enantioselective reactions.

Main Methods:

Encapsulation of hemin-G-quadruplex (Hemin-G4) DNAzyme into zeolitic imidazolate framework-90 (ZIF-90) via biomimetic mineralization.
Testing the activity and stability of encapsulated DNAzymes under various conditions (Exonuclease I, organic solvents, high temperature).
Evaluating the performance of stabilized DNAzymes in continuous-flow catalysis and enantioselective sulfoxidation reactions.

Main Results:

Encapsulation in ZIF-90 significantly increased the structural stability of the Hemin-G4 DNAzyme.
Stabilized DNAzymes exhibited sustained activity in the presence of denaturing agents and organic solvents.
The heterogeneous, stabilized DNAzyme supported continuous-flow catalysis and in situ reactivation.
High enantioselectivity was maintained for the sulfoxidation of thioanisole.

Conclusions:

Biomimetic mineralization using MOFs is an effective strategy for stabilizing DNAzymes.
Stabilized DNAzymes offer enhanced robustness, enabling applications in challenging environments and continuous processes.
This approach broadens the scope of DNAzyme applications in the chemical industry, particularly for enantioselective synthesis.