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Published on: May 4, 2018
A Systematic Review of Human Infections by Pseudomonas mendocina
Petros Ioannou1, Georgios Vougiouklakis1
1Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, 71500 Heraklion, Crete, PC, Greece.
Abstract:
Pseudomonas mendocina is a Gram-negative, rod-shaped, aerobic bacterium that belongs in the family Pseudomonadaceae and has been isolated from water and soil. Even though it is thought to cause infections quite rarely in humans, it can cause severe infections even in immunocompetent individuals. The aim of this study was to systemically review all cases of human infection by P. mendocina in the literature and describe their epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes. Thus, a systematic review of PubMed for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of Pseudomonas mendocina infections was conducted. In total, 12 studies, containing data of 16 patients, were included. The commonest P. mendocina infections were infective endocarditis, central nervous system infections and skin and soft tissue infections (SSTIs). Fever was the main presenting symptom, while sepsis was evident in almost half the patients. Pseudomonas mendocina was susceptible to most antibiotics tested. Mortality was low in all different infection types. Third or fourth generation cephalosporins and quinolones are the commonest agents used for treatment, irrespectively of the infection site.
Insights
Pseudomonas mendocina, a rare bacterial pathogen, can cause severe infections like endocarditis and CNS infections. Treatment with cephalosporins or quinolones shows good outcomes with low mortality.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Bacteriology
Background:
- Pseudomonas mendocina is a Gram-negative bacterium rarely causing human infections.
- Infections can be severe, even in immunocompetent individuals.
- Understanding P. mendocina infections is crucial for clinical management.
Purpose of the Study:
- To systematically review human infections caused by P. mendocina.
- To describe the epidemiology, microbiology, and antimicrobial susceptibility.
- To analyze treatment strategies and patient outcomes.
Main Methods:
- Systematic literature review of PubMed.
- Inclusion of studies with epidemiological, clinical, and microbiological data.
- Analysis of treatment and outcomes from 16 patient cases across 12 studies.
Main Results:
- Common infections include endocarditis, CNS infections, and SSTIs.
- Fever and sepsis were frequent symptoms.
- P. mendocina demonstrated susceptibility to most tested antibiotics.
- Mortality rates were low across all infection types.
Conclusions:
- P. mendocina infections, though rare, can be serious.
- Third/fourth generation cephalosporins and quinolones are effective treatments.
- Further research may elucidate optimal therapeutic approaches.
