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Health-Related Quality of Life Outcomes from Botulinum Toxin Treatment in Spasticity
Lorenzo Pietro Roncoroni1,2, Daniel Weiss1,2, Leonhard Hieber1,2
1Hertie-Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, 72076 Tübingen, Germany.
Objective:
The effects of botulinum toxin injections (BoNT) on health-related quality of life along the complex spectrum of spasticity needs further characterization to guide practitioners in a real-life therapeutic environment.
Methods:
In this study, we analyzed 50 consecutive and unselected patients with spasticity before and four weeks after re-injection of botulinum toxin. Health-related quality of life in terms of the EuroQol (EQ) as well as further motor and non-motor characteristics were assessed.
Results:
BoNT improved the EQ visual analog scale (EQ VAS). In addition, state of health and pain maxima improved. The EQ VAS improvement correlated with pre-injection characteristics of the EQ VAS and life satisfaction in the "movement disorders" domain.
Conclusion:
EQ VAS is sensitive for monitoring HR-QoL outcomes in an unselected real life observational cohort. This study may inform future studies intended to validate prediction variables that could inform on HR-QoL effects of BoNT treatment in spasticity.
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