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Updated: Dec 22, 2025

Murine Fetal Echocardiography
Published on: February 15, 2013
New and advanced features of fetal intelligent navigation echocardiography (FINE) or 5D heart
Lami Yeo1,2,3, Roberto Romero1,2,4,5,6
1Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA.
Insights
Fetal Intelligent Navigation Echocardiography (FINE) simplifies fetal heart screening for congenital heart disease (CHD). New features enhance ease of use and enable quantitative measurements, improving CHD detection accuracy.
Area of Science:
- Medical imaging
- Cardiology
- Prenatal diagnostics
Background:
- Congenital heart disease (CHD) is the primary cause of infant mortality due to birth defects.
- Comprehensive fetal heart screening is crucial for early detection and management of CHD.
- Four-dimensional sonography with spatiotemporal image correlation (STIC) provides dynamic cardiac imaging.
Purpose of the Study:
- To introduce novel features enhancing the Fetal Intelligent Navigation Echocardiography (FINE) method.
- To simplify the process of obtaining standard fetal echocardiography views.
- To enable quantitative measurements for improved CHD diagnosis.
Main Methods:
- Utilized "intelligent navigation" technology to interrogate STIC volume datasets.
- Developed eight advanced features for FINE, categorized by goals: simplification, quantitative measurements, and improved view acquisition.
- Features include Auto fetal positioning (FINE align), Skip points, Predictive cursor, Static mode volume, Breech sweep, Automatic cardiac axis, Cardiac biometry, and Maestro planar navigation.
Main Results:
- The new FINE features aim to further simplify fetal cardiac examinations and reduce operator dependency.
- Quantitative measurements like automatic cardiac axis and cardiac biometry are now possible.
- Enhanced features improve the success rate of obtaining essential fetal echocardiography views.
Conclusions:
- The advanced FINE features offer significant improvements in fetal echocardiography.
- These advancements enhance the sensitivity and specificity of CHD detection.
- FINE technology is integrated into commercial ultrasound platforms, aiding in widespread CHD screening.
Abstract:
Congenital heart disease (CHD) is the leading organ-specific birth defect, as well as the leading cause of infant morbidity and mortality from congenital malformations. Therefore, a comprehensive screening examination of the fetal heart should be performed in all women to maximize the detection of CHD. Four-dimensional sonography with spatiotemporal image correlation (STIC) technology displays a cine loop of a complete single cardiac cycle in motion. A novel method known as Fetal Intelligent Navigation Echocardiography (or FINE) was previously developed to interrogate STIC volume datasets using "intelligent navigation" technology. Such method allows the automatic display of nine standard fetal echocardiography views required to diagnose most cardiac defects. FINE considerably simplifies fetal cardiac examinations and reduces operator dependency. It has both high sensitivity and specificity for the detection of CHD. Indeed, FINE has been integrated into several commercially available ultrasound platforms.Recently, eight novel and advanced features have been developed for the FINE method and they will be described herein. Such features can be categorized based upon their broad goals. The first goal is to simplify FINE further, and consists of the following features: (1) Auto fetal positioning (or FINE align); (2) Skip points; (3) Predictive cursor; (4) Static mode volume; and (5) Breech sweep. The second goal is to allow quantitative measurements to be performed on the cardiac views generated by FINE: (6) Automatic cardiac axis; and (7) Cardiac biometry. Finally, the last goal is to improve the success of obtaining fetal echocardiography view(s); and consists of (8) Maestro planar navigation.
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