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The difference in the tail-flick latency between C57BL/6 and DBA/2J mice
J Vetulani1, C Castellano, W Lasoń
1Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Polish Journal of Pharmacology and Pharmacy
|January 1, 1988
Summary
Pain sensitivity in mice varies by coat color. C57BL/6 mice showed shorter tail-flick latency than DBA/2J mice, a difference attributed to coat color, not inherent pain perception.
Area of Science:
- Neuroscience
- Animal Models
- Pain Research
Background:
- Strain-specific differences in pain perception are crucial for preclinical research.
- The tail-flick test and hot-plate test are common methods for assessing nociception.
Purpose of the Study:
- To investigate interstrain differences in nociception between C57BL/6 and DBA/2J mice.
- To determine the influence of coat color on pain response measurements.
Main Methods:
- Utilized the tail-flick test with radiant heat stimulus.
- Employed the hot-plate test to assess thermal nociception.
- Conducted experiments involving tail painting to evaluate coat color effects.
Main Results:
- C57BL/6 mice exhibited significantly shorter tail-flick latencies compared to DBA/2J mice.
- No significant interstrain differences were found using the hot-plate test.
- Tail painting experiments revealed that coat color influenced tail-flick latency.
Conclusions:
- Coat color, not intrinsic nociceptive differences, likely explains the observed strain variation in the tail-flick test.
- The findings highlight the importance of controlling for confounding variables like coat color in pain research using animal models.