Related Experiment Video
Updated: Dec 22, 2025
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
[Metabolomic profiling in patients with metabolic syndrome]
E O Korobkova1, M V Kozhevnikova1, I S Ilgisonis1
1Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).
Objective:
To identify biomarkers, which are most specific for patients with metabolic syndrome (MS) using metabolomic profiling.
Materials And Methods:
Metabolomic profiling of patients with MS and comparison of their profile with the profile of volunteers was performed using high-performance liquid chromatography-mass-spectrometry.
Results:
The metabolomic profile of MS patients differed in several amino acids, including choline, cysteine, and serine and in the acylcarnitine group (р<0.05 for all comparisons).
Conclusion:
The metabolites most specific for MS patients were identified. Increased concentrations of a combination of amino acids and carnitines can be considered as possible additional risk factors for cardiovascular diseases.
