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RNA modifications in brain tumorigenesis

Albert Z Huang1, Alberto Delaidelli2,3, Poul H Sorensen4,5

  • 1Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, V5Z 1L3, Canada.

Acta Neuropathologica Communications
|May 8, 2020
PubMed

Insights

RNA modifications like m6A regulate gene expression in cancer. This review explores how these RNA changes contribute to brain tumor development and potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • RNA modifications are dynamic regulators of gene expression and protein isoforms.
  • Their deregulation is linked to various diseases, including cancer.
  • Post-transcriptional RNA modifications play crucial roles in cell proliferation and migration.

Purpose of the Study:

  • To review the role of four key RNA modifications in brain tumor pathogenesis.
  • To discuss the potential of targeting these modifications for brain tumor treatment.

Main Methods:

  • Literature review focusing on m6A, alternative polyadenylation, alternative splicing, and adenosine to inosine modifications.
  • Analysis of current research on RNA modifications in brain tumor progression.

Main Results:

  • m6A, alternative polyadenylation, alternative splicing, and adenosine to inosine modifications are implicated in brain tumor development.
  • These modifications influence gene expression and protein isoforms relevant to oncogenic properties.

Conclusions:

  • RNA modifications are critical in brain tumor progression.
  • Targeting these RNA processes offers potential therapeutic strategies for improving brain tumor prognosis.
Keywords:
Alternative polyadenylation (APA)Alternative splicingBrain tumorsGliomaInosineN6-methyladenosine (m6A)Post-translational modificationsmRNA modifications

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