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Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures
Quynh-Anh Nguyen1, Prannath Moolchand1, Ivan Soltesz1
1Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Trends in Neurosciences
|May 8, 2020
Abstract:
Epilepsy is a neurological disorder characterized by recurrent seizures, where abnormal electrical activity begins in a local brain area and propagates before terminating. In a recent study, Liou and colleagues used multiscale computational modeling to gain mechanistic insights into clinical seizure dynamics based on cellular-level biophysical properties.
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01:24Epilepsy and Seizures: Overview
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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
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Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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