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Updated: Dec 22, 2025
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Histological and Mechanical Behavior of INC 01 and 02 Bare Metal Stents Against a Commercial Stent: A Preclinical
Arturo Abundes-Velasco1, Gian Manuel Jiménez-Rodríguez2, Eduardo Arias-Sánchez2
1Subdirección de Proyectos de Innovación y Desarrollo Tecnológico, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
Background:
PCI is an expensive procedure in our population and it implies a huge cost for the institutions and National Health Service.
Aim Of The Study:
The main objective was to evaluate the technical and biological success of two stents designed in Mexico.
Methods:
Ten York pigs, 4-6 months of age, underwent implantation of the bare metal INC-01 (10 stents) and INC-02 (6 stents) coronary stent in addition to a conventional commercial stent (10 stents). Technical success was evaluated immediately with angiography and Intravascular Ultrasound IVUS, continued by a mean follow-up of 4 month and a final angiographic, IVUS and histological evaluation.
Results:
Initial technical success, angiography and IVUS between the three stents were not significant. One stent presented restenosis in follow-up (commercial stent), but all other stents presented excellent clinical outcome, satisfactory angiographic and IVUS results. Inflammation, proliferation and endothelialization between the stents had no major differences in histological analysis in a mean of 4 months follow-up.
Conclusions:
In this pig model, the INC 01 and INC 02 stents showed the same delivering technical success, angiographic and IVUS features, biological and histological response compared to commercial last generation stents.
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