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Estrogen and endometrial carcinoma.

D R Knab

    Obstetrical & Gynecological Survey
    |May 1, 1977
    PubMed
    Summary

    Endometrial carcinoma is linked to estrogen-secreting ovarian tumors and polycystic ovarian disease. Increased peripheral conversion of androgens to estrone, particularly in postmenopausal women, contributes to cancer development.

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    Area of Science:

    • Gynecology
    • Endocrinology
    • Oncology

    Background:

    • Estrogen-secreting ovarian tumors and polycystic ovarian disease are associated with endometrial carcinoma, especially in postmenopausal women.
    • Peripheral aromatization of androstenedione to estrone is increased in endometrial carcinoma patients, similar to obese and aging individuals.
    • Postmenopausal women with endometrial cancer exhibit a higher serum estrone-estradiol ratio compared to those without cancer.

    Purpose of the Study:

    • To investigate the association between estrogen metabolism and endometrial carcinoma.
    • To explore the role of peripheral estrone production in endometrial cancer development.
    • To understand the hormonal environment conducive to endometrial carcinoma in the context of age and oncogenic factors.

    Main Methods:

    • Review of existing literature on estrogen-secreting tumors, polycystic ovarian disease, and endometrial carcinoma.
    • Analysis of studies reporting peripheral conversion rates of androgens to estrone.
    • Examination of serum estrone-estradiol ratios in postmenopausal women with and without endometrial cancer.

    Main Results:

    • Estrogen-secreting ovarian tumors and polycystic ovarian disease show a consistent association with endometrial carcinoma.
    • Endometrial carcinoma patients exhibit significantly increased peripheral conversion of androgens to estrone.
    • Elevated estrone levels and a higher estrone-estradiol ratio are observed in postmenopausal women with endometrial cancer.

    Conclusions:

    • Increased peripheral estrone production, particularly in postmenopausal women with conditions like polycystic ovarian disease or ovarian tumors, is a significant factor in endometrial carcinoma development.
    • Further research is needed to elucidate the nuclear effects of estrone excess and its interaction with age and oncogenic agents.
    • While long-term exogenous estrogen use is linked to endometrial changes, prospective studies on dose and duration are required.

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