[Sleep disturbance and cognitive dysfunction in patients with persistent postural and perceptual dizziness]

Area of Science:

• Neurology
• Sleep Medicine
• Cognitive Science

Background:

• Persistent postural-perceptual dizziness (PPPD) is a chronic condition affecting balance and spatial orientation.
• The interplay between sleep quality and cognitive function in PPPD patients requires further investigation.

Purpose of the Study:

• To investigate sleep quality and cognitive status in patients diagnosed with PPPD.
• To determine the correlation between sleep quality and cognitive function in this patient group.

Main Methods:

• Seventy patients with PPPD and 70 age-matched healthy controls were assessed.
• Cognitive function was evaluated using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).
• Sleep quality was assessed via the Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG).

Main Results:

• PPPD patients exhibited mild cognitive impairment (MMSE: 25.10±3.87, MoCA: 23.10±6.11).
• Moderate insomnia was prevalent, indicated by high PSQI scores (14.60 ± 2.06).
• Significant positive correlations were found between various cognitive domains (MMSE, MoCA) and multiple sleep parameters (PSQI scores for quality, latency, duration, efficiency, disorders, and daytime dysfunction).

Conclusions:

• Moderate sleep disturbances and mild cognitive dysfunction are common comorbidities in PPPD.
• Sleep quality is significantly associated with cognitive function in PPPD patients.
• Interventions aimed at improving sleep quality may be beneficial for enhancing cognitive performance in individuals with PPPD.