[Post-thyrotoxic arterial hypertension]

The paper is concerned with the results of a study of the state of central hemodynamics, sympathetic-adrenal and renin-angiotensin systems to reveal their role in the development of postthyrotoxic arterial hypertension. Altogether 147 patients with diffuse toxic goiter before therapy and 114 patients after surgery (subtotal subfascial thyroidectomy after O. V. Nikolaev or its modification) were investigated. In 35 (30.7%) of 114 operated on patients BP values in the long-term postoperative period were above 160/95 mm Hg. Hemodynamic indices and the state of the vasoactive system were correlated. In the authors' opinion, raised activity of the sympathetic-adrenal and renin-angiotensin systems observed during decompensation of diffuse toxic goiter and progressing after surgery, led to the transformation of central hemodynamics of the hyperkinetic type into the hypokinetic one, causing the development of postthyrotoxic arterial hypertension.