Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.2K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TheraCal LC versus Mineral Trioxide Aggregate for full pulpotomy in cariously exposed mature permanent molars with symptomatic irreversible pulpitis: a randomized clinical trial.

Biomaterial investigations in dentistry·2026
Same author

Efficient real-world image denoising using multi-scale gaussian pyramids.

Scientific reports·2025
Same author

Breastfeeding, the Gut Microbiome, and Growth among Infants in Lusaka, Zambia.

The Journal of nutrition·2025
Same author

Engineering an Agro-Infectious Apple Stem Grooving Virus Clone for Virus-Induced Gene Silencing (VIGS) in Plants.

Biotechnology journal·2025
Same author

Issues related to grooming among postmastectomy patients: An Indian perspective.

Journal of education and health promotion·2025
Same author

Differential DNA methylation profiles of Alzheimer's disease-related genomic pathways in the blood of cognitively-intact individuals with and without high impact chronic pain.

Journal of Alzheimer's disease reports·2025

Related Experiment Video

Updated: Dec 22, 2025

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning
06:03

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

2.8K

Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.

Garrett Smith1, Asha Rani1, Ashok Kumar1

  • 1Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 8, 2020
PubMed
Summary
This summary is machine-generated.

Middle-aged rats show impaired beacon discrimination due to dentate gyrus (DG) gene changes. They compensate using spatial memory, linked to CA1 gene activity, offering insights into cognitive aging.

Keywords:
aginghippocampuspattern separationreference memoryspatial discriminationtranscription

More Related Videos

Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method
09:44

Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method

Published on: June 22, 2017

15.5K
Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

3.6K

Related Experiment Videos

Last Updated: Dec 22, 2025

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning
06:03

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

2.8K
Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method
09:44

Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method

Published on: June 22, 2017

15.5K
Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

3.6K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Gerontology

Background:

  • Age-related cognitive decline affects memory and gene expression in the brain.
  • The hippocampus, particularly the dentate gyrus (DG), is crucial for memory, but its role in age-related decline is not fully understood.
  • Previous studies have not linked gene expression in the DG to behavioral changes in aging.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying age-related cognitive impairments in specific hippocampal subregions.
  • To determine if a task requiring DG function could reveal age-related molecular differences.
  • To explore the relationship between gene expression in the DG and CA1 regions and performance on a spatial memory task in aging rats.

Main Methods:

  • Characterized young and middle-aged male F344 rats using a water maze beacon discrimination task and a spatial reference memory probe trial.
  • Performed mRNA sequencing on hippocampal subregions (DG and CA1) to identify differentially expressed genes (DEGs).
  • Correlated gene expression patterns with behavioral performance to link molecular changes to cognitive function.

Main Results:

  • Middle-aged rats exhibited increased variability in discriminating identical beacons, indicating impaired performance.
  • While spatial reference memory was intact, older rats relied more on it to compensate for discrimination deficits.
  • DEGs in the DG of middle-aged rats, related to synaptic function and neurogenesis, correlated with beacon discrimination performance.
  • DEGs in the CA1 region correlated with spatial memory and were linked to the regulation of neural activity.

Conclusions:

  • The dentate gyrus plays a critical role in age-related decline in beacon discrimination, evidenced by correlated gene expression changes.
  • The CA1 region's gene expression is associated with spatial memory and compensatory strategies in aging.
  • This study provides a potential animal model for studying cognitive reserve and neural compensation during aging, highlighting region-specific molecular changes in the hippocampus.