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Updated: Dec 22, 2025

High-throughput Detection Method for Influenza Virus
Published on: February 4, 2012
Estimating the COVID-19 infection rate: Anatomy of an inference problem
Charles F Manski1, Francesca Molinari2
1Department of Economics and Institute for Policy Research, Northwestern University 2211 Campus Drive, Evanston, IL 60208-2600, USA.
Abstract:
As a consequence of missing data on tests for infection and imperfect accuracy of tests, reported rates of cumulative population infection by the SARS CoV-2 virus are lower than actual rates of infection. Hence, reported rates of severe illness conditional on infection are higher than actual rates. Understanding the time path of the COVID-19 pandemic has been hampered by the absence of bounds on infection rates that are credible and informative. This paper explains the logical problem of bounding these rates and reports illustrative findings, using data from Illinois, New York, and Italy. We combine the data with assumptions on the infection rate in the untested population and on the accuracy of the tests that appear credible in the current context. We find that the infection rate might be substantially higher than reported. We also find that, assuming accurate reporting of deaths, the infection fatality rates in Illinois, New York, and Italy are substantially lower than reported.
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