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Updated: Dec 22, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers

Shaian Tavakolian1, Hossein Goudarzi1, Ebrahim Faghihloo1

  • 1Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Infectious Agents and Cancer
|May 8, 2020
PubMed

Insights

This study reviews how oncoviruses hijack cell cycle regulators, cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK), to promote cancer. Understanding these viral oncoproteins

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Cancer development involves the deregulation of cell cycle control.
  • Cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK) are key regulators of the cell cycle.
  • Oncoviruses are known to contribute to cancer progression.

Purpose of the Study:

  • To review the mechanisms by which viral oncoproteins interfere with CDK and CIK activities.
  • To explore how oncoviruses exploit cell cycle regulatory proteins for their replication and to promote malignancy.

Main Methods:

  • Literature review of studies on oncoviruses and cell cycle regulation.
  • Analysis of mechanisms involving oncoproteins from HPV, HTLV, HERV, EBV, KSHV, HBV, and HCV.
  • Focus on the interaction between viral oncoproteins and CDK/CIK pathways.

Main Results:

  • Oncoviral oncoproteins can disrupt normal CDK and CIK functions.
  • Viral proteins induce signaling pathways that facilitate viral genome replication within host cells.
  • Specific oncoproteins from various viruses demonstrate distinct strategies for cell cycle dysregulation.

Conclusions:

  • Oncoviruses play a significant role in cancer progression by manipulating cell cycle machinery.
  • Understanding these viral mechanisms is crucial for developing targeted cancer therapies.
  • Targeting the interaction between oncoproteins and cell cycle regulators presents a potential therapeutic strategy.
Keywords:
CDKCIKsCancerVirus

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