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IRISIN AND CHEMERIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Y Akgul Balaban1, N Yilmaz2, M Kalayci3
1Mecitozu State Hospital - Internal Medicine, Corum, Ministry of Health Ankara City Hospital, Istanbul, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|May 8, 2020
Summary
Newly diagnosed type 2 diabetes patients show lower irisin and higher chemerin levels compared to healthy individuals, suggesting these signaling molecules play a role in diabetes pathophysiology.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Molecular Biology
Background:
- Adipose tissue signaling molecules and inflammation are implicated in type 2 diabetes mellitus (T2DM) pathogenesis.
- Chemerin and irisin are key adipose-derived signaling molecules with roles in metabolism.
Purpose of the Study:
- To compare serum irisin and chemerin levels in newly diagnosed T2DM patients versus healthy controls.
- To investigate the association of these adipokines with T2DM.
Main Methods:
- Cross-sectional study involving 41 T2DM patients and 49 healthy controls.
- Measurement of plasma irisin and chemerin using enzyme-linked immunosorbent assay (ELISA).
- Analysis of glucose, HbA1C, insulin, HOMA-IR, and lipid profiles.
Main Results:
- Significant differences observed in glucose, HbA1C, insulin, HOMA-IR, and lipid profiles between groups.
- Lower serum irisin levels were found in newly diagnosed T2DM patients compared to controls.
- Higher serum chemerin levels were observed in newly diagnosed T2DM patients compared to controls.
Conclusions:
- Diabetes-dependent alterations in chemerin and irisin concentrations suggest their involvement in T2DM pathophysiology.
- Further research is needed to elucidate the complex signaling pathways and regulatory roles of chemerin and irisin in human metabolism.
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