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Dissolution of metronidazole from oral and vaginal dosage forms in sink and non-sink conditions
M Bećirević1, N Kallay, R Senjković
1Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia.
Abstract:
The pharmaceutical availability of metronidazole from several commercial oral and vaginal dosage forms in sink and non-sink conditions has been examined by measuring the rate of drug dissolution. The results were interpreted by means of reversible and irreversible dissolution models. For non-sink conditions the reversible model was found to better interpret the data. The values of the relative dissolution rate constant, theoretical dissolution time and dissolution efficiency were obtained and discussed.
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