First Case of an Infant with COVID-19 in the Middle East

Amani Mansour1, Rola Atoui2, Kamal Kanso1

  • 1Pediatrics and Adolescent Medicine, Lebanese University Faculty of Medicine, Beirut, LBN.

Cureus
|May 8, 2020
PubMed

Insights

A pediatric case of COVID-19 in an infant presented with severe diarrhea and fever, not respiratory symptoms. This case suggests children may clear the novel coronavirus faster than adults.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • The novel coronavirus (COVID-19) pandemic initially appeared to affect children less severely than adults.
  • Limited data exists on COVID-19 presentation and progression in infants.

Observation:

  • A 16-month-old infant presented with fever and severe diarrhea, testing positive for COVID-19.
  • The infant had no initial respiratory symptoms; chest radiography revealed lobar consolidation and bronchial infiltrates.
  • Blood culture identified *Streptococcus pneumoniae*; stool and urine cultures were negative.

Findings:

  • The infant recovered and tested negative for COVID-19 via RT-PCR after five days of antibiotic treatment (ceftriaxone and metronidazole).
  • This suggests a potentially faster viral clearance rate in children compared to adults.
  • The infant likely contracted COVID-19 from parents concealing respiratory illness due to social stigma.

Implications:

  • This case highlights the importance of considering COVID-19 in infants presenting with gastrointestinal symptoms.
  • Findings provide a reference for clinical diagnosis and treatment of pediatric COVID-19 cases.
  • Understanding transmission dynamics and symptom presentation in pediatric populations is crucial for public health strategies.

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
667
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
699
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
657
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
910
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
369