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Updated: Dec 22, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.6K

Circular RNA is a popular molecule in tumors of the digestive system (Review)

Hao-Ying Wang1, Yu-Ping Wang1, Xi Zeng1

  • 1Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

International Journal of Oncology
|May 8, 2020
PubMed

Insights

Circular RNAs (circRNAs) are non-coding RNAs playing key roles in digestive system cancers. Research highlights their potential as early diagnostic markers for improved patient prognosis in esophageal, gastric, liver, and colorectal malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Digestive system cancers (esophageal, gastric, liver, colorectal) exhibit high morbidity and mortality.
  • Lack of effective early diagnostic methods contributes to poor prognosis in these malignancies.
  • Circular RNAs (circRNAs) are non-coding RNAs with emerging roles in tumorigenesis.

Purpose of the Study:

  • To summarize the biogenesis and function of circRNAs.
  • To review the role of circRNAs in seven common digestive system tumors.
  • To explore the potential of circRNAs as diagnostic markers for digestive system malignancies.

Main Methods:

  • Literature review of circRNA biogenesis and function.
  • Analysis of circRNA involvement in tumorigenesis across seven digestive system cancers.
  • Evaluation of circRNAs as potential diagnostic biomarkers.

Main Results:

  • CircRNAs are increasingly recognized for their significant roles in cancer development.
  • Evidence suggests circRNAs can serve as valuable diagnostic markers for digestive system tumors.
  • Understanding circRNA functions offers insights into cancer progression.

Conclusions:

  • CircRNAs are crucial in the development of digestive system cancers.
  • CircRNAs show promise as novel biomarkers for early cancer detection.
  • Further research into circRNAs can advance the study of digestive system malignancies.
Keywords:
circular RNAdigestive systemcancerbiomarkertherapeutic targets

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