Related Experiment Video
Updated: Dec 22, 2025

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
[Update on vocal fold augmentation]
R Reiter1, A Pickhard2, A Heyduck3
1Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Sektion für Phoniatrie und Pädaudiologie, Universitätsklinik Ulm, Frauensteige 12, 89075, Ulm, Deutschland. Rudolf.Reiter@uniklinik-ulm.de.
Abstract:
Unilateral vocal fold palsy is a frequent cause of hoarseness. In the presence of glottis closure insufficiency, the effectiveness of conservative voice therapy is often limited and phonosurgery may be indicated. Injection laryngoplasty is effective for correction of insufficiency. Early intervention during the first 6 months after diagnosis is desired to avoid subsequent insufficient endogenous compensation. Particularly patients with glottic closure insufficiency ≤2 mm in stroboscopy may benefit from this procedure. With appropriate patient selection, duration of the effect exceeding 12 months has been described for hyaluronic acid, calcium hydroxylapatite, and autologous fat. Due to rare complications such as allergic swelling at the injection site, regular laryngoscopic monitoring and observation for two nights after injection are recommended. The voice must only be rested for a few hours.
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