Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.0K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.0K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

135
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
135

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy.

Intensive care medicine·2026
Same author

Teleconsultation in primary care: conceptual model and implementation in favela territories.

Ciencia & saude coletiva·2026
Same author

Burden of and risk factors for neurological complications in critical illness.

Intensive care medicine·2026
Same author

Lactate and Lactate Clearance as Outcome Predictors in Brain-Dead Potential Organs: A Secondary Cohort Analysis Embedded Within a Cluster-Randomized Clinical Trial.

Clinical transplantation·2026
Same author

Current knowledge and challenges of sepsis-associated encephalopathy.

Intensive care medicine·2026
Same author

Correlation Between Quantitative Pupillometry and Other Markers for Neuroprognostication of Comatose Patients After Cardiac Arrest: A Bicentric Study.

Critical care medicine·2026

Related Experiment Video

Updated: Dec 22, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.0K

Septic-Associated Encephalopathy: a Comprehensive Review.

Aurélien Mazeraud1,2,3, Cássia Righy1,4, Eleonore Bouchereau1,2,3

  • 1GHU Paris Psychiatrie et Neuroscience, Neurointensive Care and Neuroanesthesia Department, 1, rue Cabanis, 75014, Paris, France.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|May 8, 2020
PubMed
Summary
This summary is machine-generated.

Septic-associated encephalopathy (SAE) is a common complication of sepsis, impacting ICU patients and leading to worse outcomes. Management focuses on non-drug interventions like avoiding oversedation and promoting early mobility.

Keywords:
Sepsisblood–brain barriermicroglianeuroanatomyneuroinflammationsepsis-associated encephalopathy

More Related Videos

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.6K
Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

17.8K

Related Experiment Videos

Last Updated: Dec 22, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.0K
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.6K
Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

17.8K

Area of Science:

  • Neurology
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Septic-associated encephalopathy (SAE) is a frequent neurological complication in intensive care unit (ICU) patients with sepsis.
  • SAE affects up to 70% of ICU patients and is linked to increased mortality and long-term cognitive deficits.

Purpose of the Study:

  • To review the current understanding of septic-associated encephalopathy (SAE) pathophysiology and management.
  • To highlight the importance of non-pharmacological interventions in treating SAE.

Main Methods:

  • Literature review of studies on septic-associated encephalopathy.
  • Analysis of pathophysiology, diagnosis, and treatment strategies for SAE.

Main Results:

  • SAE encompasses a spectrum of neurological dysfunction, from delirium to coma.
  • Pathophysiology involves complex mechanisms including neurotransmitter dysfunction, neuroinflammation, ischemia, and blood-brain barrier disruption.
  • No definitive treatment exists; benzodiazepines should be avoided.

Conclusions:

  • Non-pharmacological strategies are crucial for managing SAE.
  • Key interventions include minimizing oversedation, promoting early mobilization, and supporting sleep hygiene.