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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Interplay between mesenchymal stem cell and tumor and potential application.

Qing Wang1, Ti Li1, Wei Wu1

  • 1Department of Dentistry, Weifang People's Hospital, Weifang, 261000, Shandong, People's Republic of China.

Human Cell
|May 8, 2020
PubMed
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Mesenchymal stem cells (MSCs) can differentiate and modulate the immune system. This review explores how MSCs interact with tumor cells, offering potential for novel cancer therapies.

Keywords:
CancerCell therapyGene delivery vehiclesMesenchymal stem cellsTumor microenvironment

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Area of Science:

  • * Stem Cell Biology and Oncology

Background:

  • * Mesenchymal stem cells (MSCs) are multipotent cells with self-renewal and differentiation capabilities.
  • * MSCs are found in various tissues and can replace damaged cells, also exhibiting immunomodulatory properties.

Purpose of the Study:

  • * To review the current understanding of Mesenchymal stem cells (MSCs) influence on tumor cells.
  • * To explore the therapeutic potential of MSCs in cancer treatment.

Main Methods:

  • * Review of existing scientific literature on MSCs and tumor microenvironment interactions.
  • * Analysis of paracrine signaling pathways between MSCs and tumor cells.

Main Results:

  • * MSCs show tropism for tumor microenvironments.
  • * MSCs interact closely with tumor cells via paracrine signaling.
  • * MSCs possess immunomodulatory functions relevant to cancer.

Conclusions:

  • * Understanding MSC-tumor cell crosstalk is crucial for developing future cancer therapies.
  • * MSCs represent a promising avenue for innovative tumor treatment strategies.