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Striatal dopamine and the interface between orienting and ingestive functions.

S Hall1, T Schallert

  • 1Department of Psychology, University of Texas, Austin 78712.

Physiology & Behavior
|January 1, 1988
PubMed
Summary
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Dopamine in the striatum is crucial for sensory attention during feeding. Eliminating this input prevents rats from orienting to stimuli while eating, suggesting dopamine’s role in disengaging from ingestive behaviors.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Neurobiology

Background:

  • Forebrain catecholaminergic projections are implicated in sensory orientation during feeding.
  • Striatal neurons respond to tactile stimuli specifically during feeding, potentially diverting attention.
  • This suggests a neural mechanism for switching attention away from ingestive behaviors.

Purpose of the Study:

  • To investigate the role of dopaminergic input to the striatum in sensory orientation during feeding behavior.
  • To determine if eliminating striatal dopamine affects the ability to disengage from ongoing feeding to orient to sensory stimuli.

Main Methods:

  • Rats received infusions of 6-hydroxydopamine directly into the striatum to lesion dopaminergic projections.
  • Animals were tested for orienting responses to tactile vibrissae stimulation during feeding and non-feeding conditions.

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Main Results:

  • While not eating, rats showed rapid orienting to tactile stimuli on either side of the body.
  • During feeding, rats failed to exhibit contralateral orienting to tactile stimuli, regardless of intensity.
  • Ipsilateral orienting during feeding remained unaffected by the lesion.

Conclusions:

  • Integrity of dopaminergic input to the striatum is essential for disengaging from ingestive behavior.
  • This pathway plays a critical role in sensory attention switching during ongoing feeding.
  • Striatal dopamine may mediate the ability to redirect attention away from motivated behaviors.