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Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions

William D G Brittain1, Steven L Cobb1

  • 1Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom.

The Journal of Organic Chemistry
|May 8, 2020
PubMed
Summary

Researchers developed a new tetrafluoropyridyl (TFP) protecting group for organic synthesis. This TFP group enables remote regiocontrol in electrophilic aromatic substitution reactions, offering novel ways to functionalize complex molecules.

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