[Required Human and System Resources for Genomic Medicine].

Area of Science:

• Genomic Medicine
• Oncology
• Clinical Sequencing

Background:

• Genomic medicine advances enable precision cancer therapies via multigene testing.
• Clinical sequencing requires multidisciplinary expertise, including pathology, bioinformatics, and genetic counseling.
• Emerging targeted therapies for hereditary cancer syndromes necessitate enhanced collaboration.

Purpose of the Study:

• To introduce PleSSision, a novel clinical sequencing system for personalized cancer medicine.
• To highlight the importance of genomic pharmacists in the evolving landscape of cancer genomic medicine.

Main Methods:

• Development and application of PleSSision, a clinical sequencing system performing amplicon exome sequencing.
• Targeting 160 cancer genes for comprehensive genomic profiling.
• Analysis of over 600 clinical cases over a 3-year period.

Main Results:

• PleSSision identified druggable gene alterations in approximately 60% of the examined cases.
• Demonstrated the feasibility and utility of the PleSSision system in clinical practice.
• Underscored the need for specialized skills and knowledge in genomics across healthcare professionals.

Conclusions:

• Precision cancer medicine relies on advanced genomic profiling and multidisciplinary collaboration.
• Genomic pharmacists play an increasingly vital role in managing patients undergoing precision cancer therapies.
• The PleSSision system facilitates the identification of therapeutic targets, advancing personalized cancer care.